POLYNUCLEOTIDES
in Harrogate & York
STIMULATE COLLAGEN, IMPROVE SKIN TONE, AND RESTORE LONG-TERM SKIN HEALTH
Polynucleotides are an advanced injectable treatment designed to stimulate your skin’s natural regenerative processes. Often described as a bio-stimulating skin booster, this powerful treatment uses DNA fragments derived from salmon to repair cellular damage, hydrate from within, and visibly improve skin quality.
At MUSE Medical Clinic™, we offer polynucleotide injections for patients seeking to soften fine lines, improve elasticity, and restore youthful luminosity, especially in delicate areas such as the under eyes, neck, and décolletage. Whether you're noticing the early signs of ageing or looking to improve skin tone and texture without adding volume, polynucleotide treatments offer a refined, non-surgical approach to long-term skin health.
DURATION
30 minutes numbing
15-30 treatment
DOWNTIME
24-72 hours
RESULTS
4 weeks
LONGEVITY
6 months
PRICE
£300
EVERYTHING YOU NEED TO KNOW ABOUT
POLYNUCLEOTIDES
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Polynucleotide treatment is an advanced injectable therapy that restores and revitalises the skin using highly purified DNA fragments derived from salmon. Often referred to as a polynucleotide skin booster or salmon sperm injection, it works by stimulating collagen and elastin production at a cellular level. Unlike dermal fillers, polynucleotide injections don’t add volume but instead encourage natural tissue repair, improving elasticity, hydration, and tone.
This bio-stimulating approach activates fibroblasts, the cells responsible for collagen and connective tissue, making it ideal for patients looking to improve skin texture, treat ageing skin, and slow down visible signs of ageing such as fine lines and sagging. Whether you're seeking a treatment for dull, tired skin or looking for an anti-aging solution that enhances your skin's natural regeneration, polynucleotides offer a subtle yet powerful response.
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Polynucleotide injections are particularly beneficial for those experiencing thinning skin, uneven tone, loss of elasticity, or early ageing. They're also suitable for patients with sensitive or post-procedure skin, thanks to their regenerative, low-risk nature.
Treatment can be used across a wide range of areas. Under the eyes, polynucleotides are a highly effective solution for reducing dark circles, fine lines and crepiness without adding bulk. On the face, they smooth forehead lines, soften crow’s feet, and restore vibrancy to the cheeks and temples. The neck and décolletage respond especially well, showing firmer, more toned skin over time. Even delicate or neglected areas like the upper lip, hands, or knees benefit from the improved elasticity and hydration this treatment delivers.
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As an injectable treatment designed to support youthful aging, polynucleotides offer a range of visible and biological benefits. They stimulate fibroblast activity, increasing collagen and elastin production and improving the skin’s natural repair function. The result is smoother, more resilient skin that looks brighter and feels healthier.
Patients often notice a softening of fine lines, enhanced skin texture, and a more even tone, particularly in areas prone to sun exposure or environmental stress. Polynucleotides also deliver deep hydration, improving skin density and structure without creating the fullness associated with dermal filler. For those asking how to stimulate collagen production in skin or searching for a gentler alternative to poly-L-lactic acid (PLLA), this regenerative treatment offers a reliable solution with low risk and high tolerance.
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All polynucleotide treatments at MUSE Medical Clinic™ are delivered by Dr Amy Watson in our medically-led aesthetic setting. The procedure begins with a full skin cleanse and the application of topical numbing cream if needed. Ultra-fine needles or a soft-tipped cannula are then used to deliver the product into precise injection sites, depending on your chosen area and treatment goals.
The entire process typically takes around 30 minutes and is focused on collagen stimulation rather than volume enhancement. Thanks to the product’s compatibility with the skin, side effects are minimal and results develop gradually, supporting a natural transformation over time.
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Following your treatment, it’s normal to experience mild redness, swelling, or small lumps at the injection site, these typically resolve within 24 to 48 hours. Bruising or tenderness may also occur but is usually short-lived. Polynucleotide injections are very well tolerated, with rare side effects such as allergic reactions discussed fully during consultation. The treatment is considered safe for most patients, even in sensitive areas like the under-eye.
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Aftercare is simple but important. You’ll be advised to avoid touching the treated area for the first few hours and skip makeup for 12 hours following your appointment. For the first 24 hours, you should cleanse gently, avoid heat (such as saunas or intense exercise), and stay away from alcohol. Applying SPF daily and maintaining hydration will also support the healing process and enhance results.
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Most patients begin to see subtle improvements in skin tone and hydration within the first 7 to 10 days. Full results become more visible after two to three sessions, as collagen production increases and the skin gradually remodels. You can expect your skin to appear brighter, smoother, and more elastic, with reduced fine lines and a fresher, more rested look, particularly under the eyes and around areas of facial movement.
Results typically last between 4 to 6 months, depending on your skin condition, lifestyle, and maintenance routine. Regular top-up treatments are recommended to maintain long-term benefits and continue supporting healthy skin ageing.
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Polynucleotide treatment pricing is based on your personalised plan and the number of sessions recommended for your goals. As a guide:
Single Session – £200
Course of Three – £500
All treatment plans begin with a detailed consultation, ensuring the procedure is right for your skin and safely delivered.
Why choose MUSE Medical™ for polynucleotide treatment?
MUSE Medical Clinic™ offers medically-led, regenerative skin treatments in a calm and clinically safe environment. Led by Dr Amy Watson, a national trainer and highly respected aesthetics doctor, our clinic is trusted by patients across Harrogate and York for delivering effective, natural-looking results.
Unlike aesthetic clinics that focus solely on appearance, we place equal emphasis on skin function and long-term skin health. Your treatment plan is always personalised, grounded in clinical experience, and delivered with care. Whether you’re seeking a single injectable treatment or an ongoing anti-aging plan, we’ll help you feel confident and well-supported at every stage.
FIND OUT IF POLYNUCLEOTIDES IS THE RIGHT TREATMENT FOR YOU
Take the next step towards firmer, brighter, and more resilient skin. Book your consultation today at MUSE Medical Clinic™ and experience the regenerative power of polynucleotides.
FREQUENTLY ASKED QUESTIONS
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Polynucleotides are regenerative injectable treatments made from purified DNA fragments that help stimulate collagen, improve elasticity, and restore skin tone and texture. By encouraging the body’s natural repair processes, they support skin regeneration, hydration, and firmness, resulting in smoother, healthier-looking skin.
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No, polynucleotides are not dermal fillers. While fillers add volume to reshape or contour, polynucleotides work at a cellular level to rejuvenate and repair the skin. They stimulate fibroblast activity, boost collagen and elastin, and enhance overall skin quality without adding fullness, making them ideal for delicate areas such as under the eyes, neck, and décolletage.
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MUSE Medical Clinic™ offers expert polynucleotide treatments in Harrogate and York, performed by experienced medical practitioners in a safe, clinical setting. Each treatment plan is bespoke, ensuring natural, refined rejuvenation tailored to your skin’s needs.
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You’ll begin to notice improvements in hydration and skin radiance within 7–10 days, as the regenerative process begins. Optimal results usually develop after a course of 2–3 treatments, spaced a few weeks apart. Skin continues to improve over the following months as collagen and elastin production increases.
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Side effects are minimal and short-lived. You may experience mild redness, swelling, or tenderness at the injection site, which typically settles within 24–48 hours. At MUSE™, all treatments are carried out by medically qualified professionals, and every patient receives tailored aftercare guidance to ensure comfort and safety.
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Yes, polynucleotides are highly effective for ageing or dull skin. They work by stimulating collagen and elastin, strengthening the skin’s structure, and reducing fine lines, sagging, and crepiness. The result is a smoother, firmer, and more luminous complexion that looks naturally refreshed rather than overfilled.