POLY-
NUCLEOTIDES
in Harrogate & York

STIMULATE COLLAGEN, IMPROVE SKIN TONE, AND RESTORE LONG-TERM SKIN HEALTH

Polynucleotides are an advanced injectable treatment designed to stimulate your skin’s natural regenerative processes. Often described as a bio-stimulating skin booster, this powerful treatment uses DNA fragments derived from salmon to repair cellular damage, hydrate from within, and visibly improve skin quality.

At Muse Medical Clinic, we offer polynucleotide injections for patients seeking to soften fine lines, improve elasticity, and restore youthful luminosity — especially in delicate areas such as the under eyes, neck and décolletage. Whether you're noticing the early signs of ageing or looking to improve skin tone and texture without adding volume, polynucleotide treatments offer a refined, non-surgical approach to long-term skin health.

DURATION

30 minutes numbing
15-30 treatment

DOWNTIME

24-72 hours

RESULTS

4 weeks

LONGEVITY

6 months

EVERYTHING YOU NEED TO KNOW ABOUT
POLYNUCLEOTIDES

  • Polynucleotide treatment is an advanced injectable therapy that restores and revitalises the skin using highly purified DNA fragments derived from salmon. Often referred to as a polynucleotide skin booster or salmon sperm injection, it works by stimulating collagen and elastin production at a cellular level. Unlike dermal fillers, polynucleotide injections don’t add volume but instead encourage natural tissue repair, improving elasticity, hydration, and tone.

    This bio-stimulating approach activates fibroblasts — the cells responsible for collagen and connective tissue — making it ideal for patients looking to improve skin texture, treat ageing skin, and slow down visible signs of ageing such as fine lines and sagging. Whether you're seeking a treatment for dull, tired skin or looking for an anti-aging solution that enhances your skin's natural regeneration, polynucleotides offer a subtle yet powerful response.

  • Polynucleotide injections are particularly beneficial for those experiencing thinning skin, uneven tone, loss of elasticity, or early ageing. They're also suitable for patients with sensitive or post-procedure skin, thanks to their regenerative, low-risk nature.

    Treatment can be used across a wide range of areas. Under the eyes, polynucleotides are a highly effective solution for reducing dark circles, fine lines and crepiness without adding bulk. On the face, they smooth forehead lines, soften crow’s feet, and restore vibrancy to the cheeks and temples. The neck and décolletage respond especially well, showing firmer, more toned skin over time. Even delicate or neglected areas like the upper lip, hands, or knees benefit from the improved elasticity and hydration this treatment delivers.

  • As an injectable treatment designed to support youthful aging, polynucleotides offer a range of visible and biological benefits. They stimulate fibroblast activity, increasing collagen and elastin production and improving the skin’s natural repair function. The result is smoother, more resilient skin that looks brighter and feels healthier.

    Patients often notice a softening of fine lines, enhanced skin texture, and a more even tone, particularly in areas prone to sun exposure or environmental stress. Polynucleotides also deliver deep hydration, improving skin density and structure without creating the fullness associated with dermal filler. For those asking how to stimulate collagen production in skin or searching for a gentler alternative to poly-L-lactic acid (PLLA), this regenerative treatment offers a reliable solution with low risk and high tolerance.

  • All polynucleotide treatments at Muse Medical Clinic are delivered by Dr Amy Watson in our medically-led aesthetic setting. The procedure begins with a full skin cleanse and the application of topical numbing cream if needed. Ultra-fine needles or a soft-tipped cannula are then used to deliver the product into precise injection sites, depending on your chosen area and treatment goals.

    The entire process typically takes around 30 minutes and is focused on collagen stimulation rather than volume enhancement. Thanks to the product’s compatibility with the skin, side effects are minimal and results develop gradually, supporting a natural transformation over time.

  • Following your treatment, it’s normal to experience mild redness, swelling, or small lumps at the injection site — these typically resolve within 24 to 48 hours. Bruising or tenderness may also occur but is usually short-lived. Polynucleotide injections are very well tolerated, with rare side effects such as allergic reactions discussed fully during consultation. The treatment is considered safe for most patients, even in sensitive areas like the under-eye.

  • Aftercare is simple but important. You’ll be advised to avoid touching the treated area for the first few hours and skip makeup for 12 hours following your appointment. For the first 24 hours, you should cleanse gently, avoid heat (such as saunas or intense exercise), and stay away from alcohol. Applying SPF daily and maintaining hydration will also support the healing process and enhance results.

  • Most patients begin to see subtle improvements in skin tone and hydration within the first 7 to 10 days. Full results become more visible after two to three sessions, as collagen production increases and the skin gradually remodels. You can expect your skin to appear brighter, smoother, and more elastic, with reduced fine lines and a fresher, more rested look — particularly under the eyes and around areas of facial movement.

    Results typically last between 4 to 6 months, depending on your skin condition, lifestyle, and maintenance routine. Regular top-up treatments are recommended to maintain long-term benefits and continue supporting healthy skin ageing.

  • Polynucleotide treatment pricing is based on your personalised plan and the number of sessions recommended for your goals. As a guide:

    Single Session – £200

    Course of Three – £500

    All treatment plans begin with a detailed consultation, ensuring the procedure is right for your skin and safely delivered.

Why choose Muse Medical for polynucleotide treatment?

Muse Medical Clinic offers medically-led, regenerative skin treatments in a calm and clinically safe environment. Led by Dr Amy Watson — a national trainer and highly respected aesthetics doctor — our clinic is trusted by patients across Harrogate and York for delivering effective, natural-looking results.

Unlike aesthetic clinics that focus solely on appearance, we place equal emphasis on skin function and long-term skin health. Your treatment plan is always personalised, grounded in clinical experience, and delivered with care. Whether you’re seeking a single injectable treatment or an ongoing anti-aging plan, we’ll help you feel confident and well-supported at every stage.

FIND OUT IF POLYNUCLEOTIDES IS THE RIGHT TREATMENT FOR YOU

Take the next step towards firmer, brighter, and more resilient skin. Book your consultation today at Muse Medical Clinic and experience the regenerative power of polynucleotides.

  • Patient review

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    “I have been to Dr Amy Watson number of times now. Discussing all my woes with my face lol. As I tend to see every wrinkle and fault ! Her advice and professionalism put me at ease and therefore take her advice for the treatments I could have and the ones I don’t need which is a good honest consultation. I have asked many questions to which Dr Amy answered everyone and is very knowledgeable and up to date with all cosmetology! Sooo friendly and kind. If your looking for someone new Dr Amy Watson is your answer. Any wait for my next appointment!”

  • Patient Review

    ☆ ☆ ☆ ☆ ☆
    “Dr Amy came very highly recommended & I can honestly say I was not disappointed... During my treatment it was very clear to me that she has a natural talent & passion for what she does. The treatment was comfortable, expertly performed & the results were amazing. I would definitely say that if you are considering any aesthetic procedure Amy is the person you should decide to put your trust in.”

  • Patient Review

    ☆ ☆ ☆ ☆ ☆
    “I have been coming to Dr Amy for 4 years now. She has always been incredibly friendly, knowledgeable and professional. She has improved the quality of my skin hugely and has advised on what would help with certain areas of concern. If you are after a natural look, Amy is your woman.”

  • Patient Review

    ☆ ☆ ☆ ☆ ☆
    “My face still looks natural and has movement but has hugely aided in its quality and prevented ageing. Amy has a real passion for helping people feel and look good, and her honesty makes her trustworthy - if you don’t need a top up she’ll tell you when some will just fill you up, take your money and send you on your way. I wouldn’t go anywhere else!”

  • Patient review

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    “Dr Amy is highly qualified and experienced in the aesthetic and beauty world. Im at that age where my neck and chest crepes and the Profilo treatment takes all of that away without surgery or neck lift. It’s not painful and the small lunps disappear the same day. I also have it on my face and it gives the skin a nice glow and fills out fine lines. So today I had a top up of Profilo and Botox around the eye area. Dr Amy I consider a friend now as I’ve been coming to her for some time as she’s very approachable and gives me lots of advice about ageing and makes me feel wonderful when leaving the salon. 10/10. Highly recommend.”

  • Patient review

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    “I’ve been a patient of Amy’s for the last two years for Profhilo. She’s an incredible cosmetic doctor. She puts you completely at ease and I can’t wait to visit her new clinic in Harrogate.”

  • Patient review

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    “I have been to see Amy twice for Masseter Botox as a result of suffering from lock jaw and TMJ pain. Having never had any cosmetic procedures before, Amy was very thorough in explaining the treatment, which made me feel at ease and showed she’s an expert in her field. I have been extremely happy with my results and would recommend her to anyone!”

  • Patient review

    ☆ ☆ ☆ ☆ ☆

    “Dr Amy is incredible! My initial consultation with her was so thorough & put me completely at ease. I’ve now had two Skin Pen treatments with her & am delighted with the results. I will be booking more treatments with her in the future & honestly can’t recommend her highly enough.”

  • Patient review

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    “Splendid lip filler. Dr Amy worked wonders with a tiny bit of lip filler. She used dental block to numb everything and her technique meant there was no bruising or lumpiness. She really improved the symmetry of my mouth and my confidence!”

  • Patient review

    ☆ ☆ ☆ ☆ ☆

    “Excellent dermal filler experience. I recently had some dermal filler with Dr. Amy and I can honestly say it was my most positive experience with filler so far. She made me feel at ease and she was great at talking me through the process step by step. I would highly recommend Face etc to anybody considering lip or general facial injectable treatment; it is certainly worth every penny to feel in such safe hands! Thanks again Amy x”

  • Patient review

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    “Amy was wonderful. I recently visited for derma filler treatment. Although having had the treatment before, I am still a real coward at the sight of a needle. It was my first time with Dr Amy, who was charming and understood my fear. She explained administration of the treatment, which differed from previous occasions. She did a great job, that was very comfortable and I am delighted with the results. What impressed me most was when I discussed treatment of another area. She was very knowledgable about this treatment, honest about how it would affect my appearance and advised that she didn't recommend it in that particular area. I left feeling happy with the effect of the treatment and her honest advice. Thank you Amy”

  • Patient review

    ☆ ☆ ☆ ☆ ☆

    “To put it simply, Muse medical clinic and the team are just incredible. I have been going to Dr Amy for close to four years now and would not dream of going anywhere else. If you love the natural look Dr Amy is the injector! The entire team is so professional and is always on hand to advise you and they truly have your best interests at heart. Their main goal is for everything to look like you but better and that really is the case. People are always shocked to hear I have had anything done and that is all thanks to Dr Amy. I can’t recommend this clinic enough. Everyone needs a Dr Amy and lily in their lives!”

  • Patient review

    ☆ ☆ ☆ ☆ ☆

    “Dr Amy was absolutely fantastic. Dr Amy was absolutely fantastic. Especially in this post-lockdown world, it can be very hard to know what to expect from a spa or clinic similar to this. All the staff were very sensible, and all the correct protective equipment was in use throughout the entire treatment. I had an excellent facial (cheek) fillers treatment, with very satisfactory results. Dr Amy was very clear in explaining the process and expected results, and incredibly gentle with the syringe. Would highly recommend.”

FREQUENTLY ASKED QUESTIONS

  • A regenerative injectable using DNA fragments to stimulate collagen, improve elasticity, and restore skin tone.

  • No — they stimulate collagen without adding volume. This makes them ideal for areas where fillers may be unsuitable.

  • Muse Medical Clinic offers polynucleotide treatments at both our Harrogate and York locations.

  • Muse Medical Clinic, in Harrogate and York, offers expert, medically-led polynucleotide treatments and is a leading skin care clinic destination.

  • Initial results appear within 7–10 days. Optimal results are seen after a course of 2–3 treatments.

  • Side effects are minimal and typically include temporary redness, swelling, or tenderness. Risks will be discussed during consultation.

  • Yes — polynucleotides improve the structure of ageing skin by stimulating collagen and elastin, visibly reducing fine lines and sagging.